![]() In contrast, when mechanical force sensing is inhibited, large amounts of free virus are released. When isolated and used as inoculum, intact virus-containing extruded cells can initiate new infections. Differential sensitivity to chemical and peptide inhibitors demonstrated that extrusion of virus-infected cells is dependent on force sensing via mechanosensitive ion channels rather than apoptotic cell death. Here we report that entire Enterovirus A71-infected cells are specifically extruded from the apical surface of differentiated human colon organoids, as observed by confocal microscopy. Picornaviruses have previously been shown to exit infected cells via either cell lysis or secretion of vesicles. However, in most cases infection is asymptomatic and limited to the gastrointestinal tract, where virus is amplified for transmission. ![]() Enterovirus A71 causes severe disease upon systemic infection, sometimes leading to life-threatening neurological dysfunction.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |